Owen Haskins - Editor in chief, Bariatric News
Bariatric surgery can result in significant improvement in nonalcoholic fatty liver disease (NAFLD), according to new research presented at Digestive Disease Week (DDW). Researchers at the University of South Florida-Tampa (USF) found that bariatric surgery resolved liver inflammation and reversed early-stage liver fibrosis, the thickening and scarring of liver tissue, by reducing fat deposits in the liver.
Dr Michael Murr
"About 30 percent of the US population suffers from this disease, which is increasing, and more than half are also severely obese," said Dr Michel Murr, lead researcher of the study, professor of surgery and director of Tampa General Hospital and USF Health Bariatric Center. "Our findings suggest that providers should consider bariatric surgery as the treatment of choice for NAFLD in severely obese patients."
Murr and his colleagues suggest that bariatric surgery be considered for patients with a BMI>35 and obesity-related co-morbidities or BMI>40. They note that traditional interventions, such as medications, have a low success rate with these patients.
Researchers compared liver biopsies from 152 patients, one at the time of the bariatric procedure and a second an average of 29 months afterwards. Mean pre-op BMI was 52±10 and mean excess body weight loss was 62±22% at the time of the subsequent biopsy.
In examining pre-operative biopsies, researchers identified patients with cellular-level manifestations of NAFLD, specifically, fat deposits and inflammation of the liver. These types of liver damage can lead to liver fibrosis and cirrhosis.
After reviewing post-operative biopsies, they found that bariatric surgery resulted in improvements for these patients. In the post-operative biopsies, researchers found that fat deposits on the liver resolved in 70 percent of patients. Inflammation was also improved, with lobular inflammation resolved in 74 percent of patients, chronic portal inflammation resolved in 32 percent, and steatohepatitis resolved in 88 percent.
In addition to these improvements, 62 percent of patients with stage two liver fibrosis had an improvement or resolution of the fibrosis. One of three patients with cirrhosis also showed improvement.
Murr noted that these findings on fibrosis reversal apply only to early-stage fibrosis, and not late-stage liver disease.
"We are in the midst of an obesity epidemic that can lead to an epidemic of nonalcoholic fatty liver disease," added Murr. "As a tool in fighting obesity, bariatric surgery could also help prevent the emergence of widespread liver disease."